alexa Thymoquinone: fifty years of success in the battle against cancer models.
Pharmaceutical Sciences

Pharmaceutical Sciences

Biochemistry & Pharmacology: Open Access

Author(s): SchneiderStock R, Fakhoury IH, Zaki AM, ElBaba CO, GaliMuhtasib HU

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Abstract Thymoquinone (TQ), the main active constituent of black seed essential oil, exhibits promising effects against inflammatory diseases and cancer. TQ, modulates signaling pathways that are key to cancer progression, and enhances the anticancer potential of clinical drugs while reducing their toxic side effects. Considering that TQ was isolated 50 years ago, this review focuses on TQ's chemical and pharmacological properties and the latest advances in TQ analog design and nanoformulation. We discuss our current state of knowledge of TQ's adjuvant potential and in vivo antitumor activity and highlight its ability to modulate the hallmarks of cancer. Copyright © 2013 Elsevier Ltd. All rights reserved. This article was published in Drug Discov Today and referenced in Biochemistry & Pharmacology: Open Access

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