Author(s): Kurtev A, Iliev E
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Abstract BACKGROUND: Autoimmune thyroiditis (AT) is often associated with alopecia areata (AA) in children and adolescents. METHODS: Forty-six children (23 girls and 23 boys), with a mean age of 9.9 +/- 3.38 years (2.24-17.5 years), were included in a study to assess thyroid function and thyroid autoantibody formation in AA. The size and function of the thyroid gland [triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and thyrotropin releasing hormone (TRH) test; fluoroimmunologic assay (FIA), Delfia], antithyroglobulin (TAT) and antimicrosomal (MAT) antibodies (microhemagglutination method), thyroid gland ultrasound, and indices of cellular and humoral immunity were assessed. RESULTS: Thyromegaly was found in 29 children (63\%). Increased basal TSH levels were present in six of the 29 (13.3\%) and hypothyroid-type stimulated secretion (TRH test) in two (out of 12). TAT was increased in 17 (39.5\%) and MAT in 14 (33.3\%) children with AA. Thyroid ultrasound examination was suggestive of AT in 13 (34.2\%) and typical of AT in five (13.2\%) children. CONCLUSIONS: We diagnosed AT in 22 of 46 children with AA (47.8\%). The immune studies revealed increased activated T lymphocytes. We recommend that thyroid gland size and function and antibody formation be examined at the diagnosis of AA and twice a year thereafter.
This article was published in Int J Dermatol
and referenced in Hair Therapy & Transplantation