alexa Thyroid dysfunction and thyroid autoimmunity in Saudi type 2 diabetics.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Akbar DH, Ahmed MM, AlMughales J

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Abstract Diabetes mellitus and thyroid disease are common endocrine disorders in the general population. To investigate the association between thyroid dysfunction, thyroid autoimmunity and Saudi type 2 diabetics, a random sample of 100 Saudi type 2 diabetics and 100 age- and sex-matched controls were studied. The mean age was 54 years for diabetics and 55 years for controls while the male:female ratios were 1:1.6 and 1:14 respectively. GAD65ab were found in 26\% diabetics and 2\% controls (p=0.001). Thyroid autoimmunity were detected in 10\% diabetics vs. 5\% controls (p=0.05), while thyroid dysfunction was found in 16\% and 7\% respectively (p=0.03). In GAD65ab-positive diabetics, thyroid autoimmunity was observed in 27\% vs. 4\% GAD65ab-negative diabetics (p=0.02) and thyroid dysfunction was reported in 42\% and 7\% respectively. We conclude that thyroid dysfunction and autoimmunity are common in Saudi type 2 diabetics. Further studies are needed on the cost effectiveness of thyroid screening in diabetics. This article was published in Acta Diabetol and referenced in Journal of Glycomics & Lipidomics

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