alexa Tight control in the treatment of rheumatoid arthritis: efficacy and feasibility.


Journal of Arthritis

Author(s): Bakker MF, Jacobs JW, Verstappen SM, Bijlsma JW

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Abstract OBJECTIVE: To evaluate the available evidence on the efficacy and feasibility of the new concept of tight control in randomised trials in patients with rheumatoid arthritis (RA). Tight control is a treatment strategy tailored to the individual patient with RA, which aims to achieve a predefined level of low disease activity or remission within a certain period of time. METHODS: The literature database PubMed was searched and yielded four trials: the FIN-RACo trial, the TICORA study, the BeSt study and the CAMERA study. RESULTS: Tight control resulted in greater improvement and a higher percentage of patients meeting the preset aim of low disease activity or remission when compared to the control intervention. In the FIN-RACo trial, analysing the subset of patients completing the study, 68\% in the tight control group achieved remission (DAS28<2.6) verus 41\% in the contrast group [corrected] In the TICORA study, 65\% of patients in the tight control group versus 16\% of the contrast group achieved remission, based on DAS<1.6 (p<0.0001). In the CAMERA study, 50\% of patients in the tight control group using a computer decision model achieved remission, versus 37\% in the contrast group (p = 0.029). The BeSt study consisted of only tight control groups aimed at a DAS<1.6; remission was achieved in 38-46\% of patients. This is higher than the range of remission in earlier trials of 13-36\%. CONCLUSION: Tight control aiming for low disease activity or even better still, remission, seems a promising option in treating patients with RA in clinical trials and probably also in daily practice.
This article was published in Ann Rheum Dis and referenced in Journal of Arthritis

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