alexa TIM-3 as a therapeutic target in human inflammatory diseases.


Journal of Clinical & Cellular Immunology

Author(s): Anderson DE

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Abstract T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) was the first, and is presently the only, surface molecule that can specifically identify T(H)1 cells in both mice and humans. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. This article was published in Expert Opin Ther Targets and referenced in Journal of Clinical & Cellular Immunology

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