Author(s): Choi HS, Ipe BI, Misra P, Lee JH, Bawendi MG,
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Abstract A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
This article was published in Nano Lett
and referenced in Pharmaceutica Analytica Acta