alexa Tissue engineered fetal skin constructs for paediatric burns.
Surgery

Surgery

Reconstructive Surgery & Anaplastology

Author(s): Hohlfeld J, de Buys Roessingh A, HirtBurri N, Chaubert P, Gerber S,

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Abstract Autologous skin-grafting is the gold standard for treatment of deep second and third degree burns. Available bioengineered skin products also necessitate this two-step surgical procedure. Therefore, we developed fetal skin constructs to improve healing of such degree burns. A bank of fetal skin cells was developed from one organ donation (4 cm2 of skin allowing the preparation of several million three-dimensional skin constructs, 9x12 cm, on native horse collagen). Successive fetal constructs were applied to eight patients at every change of dressing during 1-3 weeks in an outpatient setting. Complete closure was rapid (mean 15.3 days [SD 5.5]) with little hypertrophy of new skin and no retraction seen. This simple technique provided complete treatment without auto-grafting, showing that fetal skin cells might have great potential to treat burns and eventually acute and chronic wounds of other types. This article was published in Lancet and referenced in Reconstructive Surgery & Anaplastology

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