Author(s): Poppe WA, Ide PS, Drijkoningen MP, Lauweryns JM, Van Assche FA
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Abstract Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia.
This article was published in Gynecol Obstet Invest
and referenced in Journal of Antivirals & Antiretrovirals