alexa Toll-like receptor 4 gene polymorphisms and acute coronary syndrome: no association in a Mexican population.


Immunotherapy: Open Access

Author(s): MartnezRos MA, VargasAlarcn G, Vallejo M, CruzMartnez E, PrezMndez O, , MartnezRos MA, VargasAlarcn G, Vallejo M, CruzMartnez E, PrezMndez O, , MartnezRos MA, VargasAlarcn G, Vallejo M, CruzMartnez E, PrezMndez O, , MartnezRos MA, VargasAlarcn G, Vallejo M, CruzMartnez E, PrezMndez O,

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Abstract OBJECTIVE: The objective of this study was to establish the role of the TLR-4 gene polymorphisms in individuals in risk of developing ACS. METHODS: The study included 457 Mexican patients with ACS and 283 control individuals. The TLR-4 Asp299Gly and TLR-4 Thr399Ile single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays on an 7900HT Fast real-time PCR system according to manufacturer's instructions (Applied Biosystems, Foster City, USA). RESULTS: The results obtained in this study showed that the frequency of the two polymorphisms (TLR-4 Asp299Gly and TLR-4 Thr399Ile) studied were similar between patients with ACS and healthy controls. Multiple logistic regression analysis showed that the largest risk factor for ACS development was given by smoking (11.88-fold increased risk), hypertension (4.32-fold increased risk), type II diabetes (3.44-fold increased risk), gender (2.32-fold increased risk), and dyslipidemia (1.52-fold increased risk). CONCLUSION: The Asp299Gly and Thr399Ile polymorphisms were not associated with susceptibility to ACS in the Mexican population. Copyright © 2012 Instituto Nacional de Cardiología Ignacio Chávez. Published by Masson Doyma México S.A. All rights reserved. This article was published in Arch Cardiol Mex and referenced in Immunotherapy: Open Access

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