alexa Tor complex 1 controls telomere length by affecting the level of Ku.
Genetics & Molecular Biology

Genetics & Molecular Biology

Fungal Genomics & Biology

Author(s): Ungar L, Harari Y, Toren A, Kupiec M

Abstract Share this page

Abstract Telomeres are specialized DNA-protein structures at the ends of eukaryotic chromosomes. Telomeric DNA is synthesized by telomerase, which is expressed only at the early stages of development [1, 2]. To become malignant, any cell has to be able to replenish telomeres [3]. Thus, understanding how telomere length is monitored has significant medical implications, especially in the fields of aging and cancer. In yeast, telomerase is constitutively active. A large network of genes participates in controlling telomere length [4-8]. Tor1 and Tor2 (targets of rapamycin [9]) are two similar kinases that regulate cell growth [10]. Both can be found as part of the TOR complex 1 (TORC1 [11]), which coordinates the response to nutrient starvation and is sensitive to rapamycin [12]. The rapamycin-insensitive TOR complex 2 (TORC2) contains only Tor2 and regulates actin cytoskeleton polarization [13]. Here we provide evidence for a role of TORC1 in telomere shortening upon starvation in yeast cells. The TORC1 signal is transduced by the Gln3/Gat1/Ure2 pathway, which controls the levels of the Ku heterodimer, a telomere regulator. We discuss the potential implications for the usage of rapamycin as a therapeutic agent against cancer and the effect that calorie restriction may have on telomere length. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Curr Biol and referenced in Fungal Genomics & Biology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • World Congress on Mycology
    September 11-13, 2017 Los Angeles, USA
  • International Conference on Microbial Ecology
    September 18-20, 2017 Toronto, Canada
  • International Conference on Fungal Diseases & Control
    September 25-26, 2017 Dubai, UAE
  • 2nd International Conference on Mycology & Mushrooms
    September 25-26, 2017 Chicago, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version