alexa Torque teno virus in fecal samples of patients with gastroenteritis: prevalence, genogroups distribution, and viral load.


Journal of Vaccines & Vaccination

Author(s): PinhoNascimento CA, Leite JP, Niel C, DinizMendes L

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Abstract Torque teno virus (TTV, genus Alphatorquevirus, family Anelloviridae) is a DNA virus, highly prevalent in populations from around the world. TTV isolates have been classified into five main phylogenetic groups (1-5) showing a large genetic distance between them. The presence of TTV has been detected in feces. However, whether all five TTV genogroups are excreted in feces and the frequency of these events are presently unknown. The presence of TTV DNA was assessed in feces from 135 Brazilian (0-90 years old) patients with gastroenteritis by using three PCR methods, including real-time PCR. One hundred twenty one (91.1\%) samples were positive with at least one method. Using a genogroup-specific assay, it was shown that all genogroups were present. Thirty-seven (27.4\%), 27 (20.0\%), 57 (42.2\%), 29 (21.5\%), and 33 (24.4\%) fecal samples contained TTV isolates belonging to genogroups 1-5, respectively. Coinfections with two, three, four, and five TTV genogroups were found in 23 (17.0\%), 15 (11.1\%), 7 (5.2\%), and 7 (5.2\%) fecal samples, respectively. Thus, 52 (38.5\%) samples contained more than one TTV genogroup. Viral loads ranged from 2.6 to 6.5 log genome equivalents per gram of feces. However, only moderate variations of viral load were noted depending on genogroup and number of coinfecting TTV genogroups. These results show a high prevalence and a diversity of TTV isolates in feces. Copyright © 2011 Wiley-Liss, Inc. This article was published in J Med Virol and referenced in Journal of Vaccines & Vaccination

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