alexa Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi.
Microbiology

Microbiology

Journal of Microbial & Biochemical Technology

Author(s): Lim FY, Sanchez JF, Wang CC, Keller NP

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Abstract Mining for novel natural compounds is of eminent importance owing to the continuous need for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic capacity for an arsenal of natural compounds, both beneficial and detrimental to humans. The majority of these metabolites are still cryptic or silent under standard laboratory culture conditions. Mining for these cryptic natural products can be an excellent source for identifying new compound classes. Capitalizing on the current knowledge on how secondary metabolite gene clusters are regulated has allowed the research community to unlock many hidden fungal treasures, as described in this chapter. Copyright © 2012 Elsevier Inc. All rights reserved.
This article was published in Methods Enzymol and referenced in Journal of Microbial & Biochemical Technology

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