Author(s): Ryan D, Rahimi M, Lund J, Mehta R, Parviz BA
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Abstract This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and perform measurements using novel nano-scale effects has provided new opportunities to identify nucleotides directly using physical, and not chemical, methods. The challenges that these technologies need to overcome to provide a US$1000-genome sequencing technology are also presented.
This article was published in Trends Biotechnol
and referenced in Journal of Nanomedicine & Nanotechnology