alexa Toxicity of daily low dose cisplatin in radiochemotherapy for locally advanced head and neck cancer.


Journal of Oncology Translational Research

Author(s): Wolff HA, Overbeck T, Roedel RM, Hermann RM, Herrmann MK,

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Abstract PURPOSE: To evaluate toxicity of radiochemotherapy schedule using daily-low-dose-cisplatin in radiochemotherapy of locally-advanced head-and-neck-cancer (HNSCC). METHODS AND PATIENTS: From October 2003 to October 2006, 50 patients with HNSCC (stage III/IVA/IVB) were treated. In 32 patients, surgery and adjuvant radiotherapy(64 Gy), in 18 patients definitive radiotherapy(70 Gy) was performed. Low-dose-cisplatin was applied concomitantly (6 mg/m2/every radiotherapy-day). RESULTS: Acute toxicity > or =grade 3 was observed in 22 patients (11 patients mucositis/dysphagia, 7 hematologic toxicity, 4 mucositis/dysphagia/hematologic toxicity). 90\% of our patients received >80\% of the planned cumulative chemotherapy dose, 94\% the intended dose of radiotherapy. After median follow-up of 24.2 months, 3-year overall survival and loco-regional control rates were 67.1 and 78\%. During follow-up, chronic toxicity > or =grade 3 (xerostomia, subcutaneous fibrosis, or lymphedema) was observed in nine patients. CONCLUSION: We found chemoradiation with daily-low-dose-cisplatin to be feasible with advantage of low acute and chronic toxicity. Therefore, use of low-dose-cisplatin should be evaluated in future clinical trials.
This article was published in J Cancer Res Clin Oncol and referenced in Journal of Oncology Translational Research

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