alexa Toxicity of nano zinc oxide to mitochondria
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Jiahan Li, Xiaorong Liu, Yue Zhang, Fangfang Tian, Guangyuan Zhao, Qiuliyang Yu, Fenglei Jiang, Yi Liu

Abstract Share this page

Zinc oxide nanoparticles (ZnO NPs) are increasingly applied in a diverse array of industrial and commercial products. Therefore, it is urgently required to characterize their toxic behavior. ZnO NPs have been reported to induce toxic effects at the levels of the individual organism, tissue, cell and DNA. However, little is known about the potential impacts of ZnO NPs at a subcellular level. In the present work, we investigated the toxicity of ZnO NPs to the isolated rat liver mitochondria. We found that treatment of mitochondria with ZnO NPs resulted in collapse of mitochondrial membrane potential (Δψ), swelling, depression of respiration, inner membrane permeabilization to H+ and K+, alterations of ultrastructure, release of cytochrome c, generation of reactive oxygen species (ROS), and Zn2+ liberation from ZnO NPs. These results suggested that ZnO NPs can increase the inner membrane permeability and impair the respiratory chain, thus leading to energy dissipation, oxidative stress and even apoptosis. This putative mechanism helps us learn more about the toxicology of this nanomaterial.

  • To read the full article Visit
  • Subscription
This article was published in Toxicolody Research and referenced in Biochemistry & Analytical Biochemistry

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords