Author(s): Allegaert K, de Hoon J, Verbesselt R, Devlieger H, Tibboel D
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Abstract Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.
This article was published in Eur J Clin Pharmacol
and referenced in Journal of Clinical Case Reports