alexa Tranexamic acid to reduce blood loss after bilateral total knee arthroplasty: a prospective, randomized double blind study.
Haematology

Haematology

Journal of Blood Disorders & Transfusion

Author(s): MacGillivray RG, Tarabichi SB, Hawari MF, Raoof NT, MacGillivray RG, Tarabichi SB, Hawari MF, Raoof NT

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Abstract The effects of 2-dosage regimens of tranexamic acid (10 mg/kg and 15 mg/kg) on blood loss and transfusion requirement were compared to saline placebo in 60 patients undergoing concurrent bilateral total knee arthroplasty, with additional reinfusion autotransfusion from intraarticular drains. Mean blood loss was 462 mL in 15 mL/kg group, 678 mL in 10 mg/kg group, and 918 mL in controls (P < .01 vs 15 mg/kg). Blood available for autotransfusion was greatest in controls and least in 15 mg/kg group. Combined autologous and allogenic transfusion volumes were similar in the treatment groups and significantly less than controls (P < .01). With use of an autologous reinfusion strategy, the lower dose is sufficient to lead to a lesser allogenic transfusion requirement. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in J Arthroplasty and referenced in Journal of Blood Disorders & Transfusion

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