alexa Transfer of methadone across the dually perfused preterm human placental lobule.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Nanovskaya TN, Nekhayeva IA, Hankins GD, Ahmed MS

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Abstract OBJECTIVE: The objective of the study was to determine the effect of gestational age and P-glycoprotein expression on transplacental transfer of methadone. STUDY DESIGN: Dual perfusion of placental lobule was utilized. Methadone (200 ng/mL) and its [3H]-isotope were cotransfused from the maternal-to-fetal circuit with the marker compound antipyrine (20 microg/mL) and its [14C]-isotope. Concentration of the drugs in trophoblast tissue and both circuits was determined by liquid scintillation spectrometry. RESULTS: Fetal transfer rate of methadone in preterm placentas was 19 +/- 5.8\%, and in term placentas it was 31 +/- 9.7\% (P < .01). Clearance index of methadone in preterm placentas (0.57 +/- 0.2) was lower than in term placentas (0.95 +/- 0.3, P < .01). P-glycoprotein expression was higher in preterm than term placentas. CONCLUSION: The ex vivo transfer of methadone across preterm placentas is 30\% lower than in term placentas. This article was published in Am J Obstet Gynecol and referenced in Pharmaceutica Analytica Acta

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