Author(s): Sporn MB, Roberts AB, Wakefield LM, Assoian RK
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Abstract Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.
This article was published in Science
and referenced in Journal of Clinical & Experimental Dermatology Research