alexa Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Prokurat A, Kluge P, Kociesza A, Perek D, Kappeler A,

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Abstract BACKGROUND: We encountered on seven malignant hepatocellular tumors developing in older children and adolescents. RESULTS: These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis. CONCLUSION: We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions. Copyright 2002 Wiley-Liss, Inc. This article was published in Med Pediatr Oncol and referenced in Journal of Carcinogenesis & Mutagenesis

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