alexa Transposable elements have rewired the core regulatory network of human embryonic stem cells.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Kunarso G, Chia NY, Jeyakani J, Hwang C, Lu X,

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Abstract Detection of new genomic control elements is critical in understanding transcriptional regulatory networks in their entirety. We studied the genome-wide binding locations of three key regulatory proteins (POU5F1, also known as OCT4; NANOG; and CTCF) in human and mouse embryonic stem cells. In contrast to CTCF, we found that the binding profiles of OCT4 and NANOG are markedly different, with only approximately 5\% of the regions being homologously occupied. We show that transposable elements contributed up to 25\% of the bound sites in humans and mice and have wired new genes into the core regulatory network of embryonic stem cells. These data indicate that species-specific transposable elements have substantially altered the transcriptional circuitry of pluripotent stem cells. This article was published in Nat Genet and referenced in Journal of Stem Cell Research & Therapy

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