alexa Transposition of the great arteries and hypocalcemia in a patient with fetal hydantoin syndrome.


Journal of Neonatal Biology

Author(s): Shah MK, Morava E, Gill W, Marble MR

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Abstract We report a patient with fetal hydantoin syndrome (FHS) with associated d-transposition of the great arteries (d-TGA) and persistent hypocalcemia. d-TGA and hypocalcemia have each been individually reported once in association with FHS, but these patients were also prenatally exposed to phenobarbital. To our knowledge, this is the first report of these problems occurring after prenatal exposure to hydantoin alone. The combination of congenital heart disease and hypocalcemia in our patient raises the possibility of a hydantoin effect on neural crest migration. This article was published in J Perinatol and referenced in Journal of Neonatal Biology

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