Author(s): Zaphiropoulos PG, Zaphiropoulos PG, Zaphiropoulos PG, Zaphiropoulos PG
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Abstract Trans-splicing, the possibility of exons from distinct pre-mRNAs to join together, is still a concept in gene expression that is generally regarded of limited significance. However, recent work has provided evidence that in human tumors trans-splicing events may precede chromosomal rearrangements. In fact, it has been suggested that the trans-spliced molecules could act as "guides" that facilitate the genomic translocation. This perspective highlights the development of the ideas of trans-splicing in higher eukaryotes during the last 25 years, from a bizarre phenomenon to a biological event that is attaining stronger recognition.
This article was published in Front Genet
and referenced in Diagnostic Pathology: Open Access