alexa Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms.


Journal of Integrative Oncology

Author(s): Bijelic L, Yan TD, Sugarbaker PH

Abstract Share this page

Abstract BACKGROUND: Peritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy. Despite its efficacy, recurrences remain a common problem. METHODS: Patients with peritoneal dissemination from appendiceal or colorectal malignancy who underwent complete cytoreduction and perioperative intraperitoneal chemotherapy were included in this study. Data regarding recurrent disease found on abdominal exploration and/or diagnostic studies was extracted from a prospective database and analyzed. RESULTS: Seventy patients with colorectal cancer carcinomatosis and 402 with appendiceal neoplasm were analyzed. Forty-nine of 70 and 111 of 402 patients developed documented recurrences. The median survival of 49 patients with colorectal cancer was 33 months while the median survival for patients with appendiceal neoplasms was not reached. The most common type of recurrent disease was a localized intra-abdominal recurrence for both appendiceal and colon cancer patients. Patients who underwent second surgery for recurrent disease had an improved survival. CONCLUSION: Additional treatments should be strongly considered in patients who fail an initial cytoreduction combined with perioperative intraperitoneal chemotherapy. This resulted in 5-year survival in 17\% of colorectal patients and 70\% of the appendiceal mucinous neoplasm patients. This article was published in J Surg Oncol and referenced in Journal of Integrative Oncology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

1-702-714-7001Extn: 9042

General Science

Andrea Jason

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001Extn: 9042

© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version