Author(s): Al Khaja KA, Sequeira RP, Damanhori AH
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Abstract OBJECTIVE: To evaluate the adequacy of blood pressure (BP) control and therapeutic appropriateness of antihypertensive drug(s) prescribed, taking into consideration laboratory parameters and the presence of comorbidities, in hypertensive patients. METHODS: Therapeutic audit of medical records of hypertensive patients from 9 primary care health centers in Bahrain using World Health Organization/International Society of Hypertension guidelines criteria. RESULTS: The recommended target BP <140/<90 mmHg was achieved in 37 (16.5\%) patients with a mean BP of 126 +/- 6 / 80 +/- 5 mmHg. Groups with inadequate BP control were 15 (6.7\%) with normal systolic BP (SBP) and high diastolic BP (DBP), 59 (26.3\%) with high SBP and normal DBP, and 113 (50.4\%) with high SBP and high DBP. Pulse pressure of the controlled group was 46.3 +/- 5.9, whereas pulse pressures of the inadequately controlled groups with BP cutoffs <140/> or =90, > or =140/<90, and > or =140/> or =90 mmHg were 37.4 +/- 6.1, 72.7 +/- 13.5, and 59.7 +/- 13.6 mmHg, respectively. Of the 281 treated hypertensive patients, 56.6\% were on monotherapy; BP of patients on combination therapy versus monotherapy did not differ. The choice of antihypertensives in relation to comorbidities and laboratory findings revealed that many hypertensive patients with dyslipidemia were on beta-blockers and diuretics, 39.3\% of patients with ischemic heart disease were on beta-blockers, approximately 20\% of patients with hyperuricemia were on diuretics, and 27.6\% and 10.4\% of patients with isolated systolic hypertension were on diuretics and calcium-channel blockers, respectively. CONCLUSIONS: BP control was achieved in 1 of 6 treated patients. In several instances, metabolic abnormalities and comorbidities were apparently not considered while prescribing antihypertensives. A rational drug therapy approach is needed in treating hypertension to achieve better control rates.
This article was published in Ann Pharmacother
and referenced in Journal of Hypertension: Open Access