alexa Treatment of severe acute hepatitis E by ribavirin.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Gerolami R, Borentain P, Raissouni F, Motte A, Solas C,

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Abstract BACKGROUND: Acute hepatitis E is associated with a higher rate of mortality as compared to hepatitis A or B infections in some series. To date no treatment has been recommended for acute hepatitis E. However, ribavirin has been recently reported to be highly effective to treat solid-organ-transplant recipients chronically infected with hepatitis E virus (HEV). OBJECTIVE AND STUDY DESIGN: We report here on the use of ribavirin to treat severe acute HEV infection in a non-immunocompromized patient. This 61-year-old-man presented with acute hepatitis with HEV genotype 3. Seven days after admission, prothrombin index was 38\%, bilirubinaemia was 550 μmol/L and alanine aminotransferases level was still increasing, reaching 4565IU/L. No hepatic encephalopathy was noted. Ribavirin (1200 mg/day) was introduced. RESULTS: Liver biological tests showed rapid improvement concurrently with a decrease in HEV RNA levels in serum samples. Therapy was interrupted after 21 days. At that time, ALT had normalized, bilirubinemia was 138 μmol/L, and HEV RNA was almost undetectable in the serum. CONCLUSION: Ribavirin therapy could be an effective treatment of severe acute hepatitis E. Copyright © 2011 Elsevier B.V. All rights reserved. This article was published in J Clin Virol and referenced in Journal of Antivirals & Antiretrovirals

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