alexa Trypanocidal and leishmanicidal properties of substitution-containing chalcones.


Medicinal Chemistry

Author(s): Lunardi F, Guzela M, Rodrigues AT, Corra R, EgerMangrich I,

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Abstract Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.
This article was published in Antimicrob Agents Chemother and referenced in Medicinal Chemistry

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