alexa Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?


Journal of Clinical & Cellular Immunology

Author(s): Mellor AL, Munn DH

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Abstract Some macrophages inhibit microbial infections by producing indoleamine 2,3 dioxygenase (IDO), which catabolizes tryptophan. Here, Andrew Mellor and David Munn discuss evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell attack and argue that this mechanism might have wider implications for the control of T-cell responses.
This article was published in Immunol Today and referenced in Journal of Clinical & Cellular Immunology

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