alexa Tumor necrosis factor alpha-308 and Lymphotoxin alpha+252 genetic polymorphisms and the susceptibility to non-Hodgkin lymphoma in Egypt.
Immunology

Immunology

Immunogenetics: Open Access

Author(s): Azza Ibrahim, Hala Abdel Rahman, Mervat Khorshied, Rania Sami, Nelly Nasr

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Genetic polymorphism within the regulatory regions of tumor necrosis factor-alpha (TNF-α) and Lymphotoxin-alpha (LT-α) may be involved in the development of lymphoid malignancies. The aim of the current study was to investigate the effect of TNFα-308 and LTα+252 genetic polymorphism on susceptibility to non-Hodgkin lymphoma (NHL) in Egypt. Genotyping of the studied genes by restriction fragment length polymorphism polymerase chain reaction was conducted on 84 NHL and 100 healthy controls and revealed that TNFα-308 homotype (AA) was significantly higher in NHL patients and conferred sixfold increased risk of NHL (OR=5.9, 95%CI=2.3-16.1). Moreover, TNFα/LTα high-producer haplotypes were significantly higher in NHL patients and conferred increased risk of NHL (OR=4.59, 95%CI=2.19-9.42).

This article was published in Leukemia Research and referenced in Immunogenetics: Open Access

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