alexa Tumor recurrence following resection for early gastric carcinoma and its implications for a policy of limited resection.
Surgery

Surgery

Journal of Surgery

Author(s): Namieno T, Koito K, Higashi T, Shimamura T, Yamashita K,

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Abstract Some patients suffer postoperative recurrence after curative resection of early gastric carcinoma. This study reviewed consecutive patients with a single primary lesion and analyzed the relation between the pathologic findings and recurrence of early gastric carcinomas for determining indications for limited surgery. Among the 1585 consecutive patients with a solitary primary lesion of an early gastric carcinoma who had undergone curative surgery between 1963 and 1989 at one general hospital, pathologic findings relating to recurrence were analyzed according to Japan's General Rules for Gastric Cancer Study in Surgery and Pathology. Of these carcinomas, mucosal carcinomas comprised 701 (44.2\%) and submucosal ones 884 (55.8\%). The total recurrence rate in this series was 1.0\%. Submucosal carcinomas (1.6\%) were significantly (p < 0.02) more recurrent than mucosal ones (0.29\%). Of the 16 patients with recurrence, 10 (62.5\%) died within 5 years after surgery, frequently because of blood-borne metastasis. Macroscopically elevated components, the degree of histologic differentiation, and lymph node metastasis significantly contributed to the postoperative recurrence. After detailed analysis of submucosal carcinomas, it is strongly suspected that carcinomas with a macroscopically elevated component were significantly associated with nodal involvement and microvessel invasion, and that these abnormalities lead to recurrence. Among the early gastric carcinomas, differentiated submucosal carcinomas with a macroscopically elevated component, lymph node metastasis, or both have the most potential of recurrence after surgery. Mucosal carcinomas must be restricted to limited surgery, but, blood-borne metastasis should be carefully avoided.
This article was published in World J Surg and referenced in Journal of Surgery

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