alexa Tumor-specific MAGE proteins as regulators of p53 function.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Ladelfa MF, Peche LY, Toledo MF, Laiseca JE, Schneider C,

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Abstract Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. This article was published in Cancer Lett and referenced in Journal of Genetic Syndromes & Gene Therapy

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