Author(s): Dimmeler S, Zeiher AM, Schneider MD
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Abstract In humans, the biological limitations to cardiac regenerative growth create both a clinical imperative--to offset cell death in acute ischemic injury and chronic heart failure--and a clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell number or in other ways promote more efficacious cardiac repair. Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target.
This article was published in J Clin Invest
and referenced in Journal of Genetic Syndromes & Gene Therapy