alexa Under pressure: stromal fibroblasts change their ways.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Bierie B, Moses HL

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Abstract In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression. This article was published in Cell and referenced in Journal of Cytology & Histology

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