alexa Understanding the mechanism of the water drinking test: the role of fluid challenge volume in patients with medically controlled primary open angle glaucoma.
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Kerr NM, DaneshMeyer HV

Abstract Share this page

Abstract BACKGROUND: To determine whether a 500-mL fluid challenge produces a different intraocular pressure (IOP) response profile compared with a 1000-mL water drinking test (WDT). METHODS: Prospective, observer-masked, cross-over, observational study. Patients with primary open angle glaucoma were recruited from a private specialist glaucoma practice. One eye of each patient was included. Subjects were randomized to receive either a 500-mL or 1000-mL fluid challenge. Baseline IOP was recorded with a Goldmann applanation tonometer and then every 15 min for 1 h. A second WDT with the alternate volume of water was performed after a minimum washout period of 24 h. Primary statistical analysis was performed using a two-way anova repeated measures of variance with a Bonferroni post-hoc test. RESULTS: Fifteen patients were included in this study. The mean patient age was 67.0 +/- 10.2 (SD) years, and 60\% of patients were female. There was no statistically significant difference in baseline IOP between the 500-mL and 1000-mL WDTs (P = 0.11). Both fluid challenge volumes produced a statistically significant rise in IOP from baseline at 15, 30 and 45 min after water ingestion. However the mean maximum increase in IOP was less in the 500-mL WDT (3.3 +/- 1.8 mmHg [23.9\%]) compared with the 1000-mL WDT (4.9 +/- 2.3 mmHg [32.5\%]; P = 0.0095). CONCLUSION: The 500-mL WDT may provide an alternative for patients who are unable to tolerate drinking 1000 mL of water. However, because the maximum IOP obtained is less, a 500-mL WDT cannot be used to directly estimate peak diurnal pressure. This article was published in Clin Exp Ophthalmol and referenced in Journal of Clinical & Experimental Ophthalmology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords