alexa Unwanted interactions among psychotropic drugs and other treatments for autism spectrum disorders
Reproductive Medicine

Reproductive Medicine

Clinics in Mother and Child Health

Author(s): Theoharides TC, Asadi S

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Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders affecting approximately 1% of children and characterized by varying degrees of deficiencies in social interactions, concentration, language, learning, and as stereotypic behaviors.1Y3 Many children develop ASD by regression at approximately age 3 years, often after a specific event such as vaccination or infection, although they were developing normally.4,5 Some gene variants in ASD confer altered vulnerability to environmental stressors and exposures.6 Behavioral interventions alone are not sufficient to adequately address the disruptive nature of ASD symptoms and their persistence throughout life.7,8 Instead, psychotropic drug therapy is typically used to treat irritability, hyperactivity, inattention, obsessive-compulsive symptoms, aggression, and self-injury.9Y11 Many children with ASD also develop seizures with no apparent underlying pathological cause,12Y14 but traditional antiseizure medications seem to worsen ASD symptoms.15 Overall, 70% of children with ASD take at least 10 different drugs, dietary supplements, vitamins, or other treatments10,16Y18 including intravenous immunoglobulin.19 Secretin is also commonly used although it has no effect20 and could lead to the risk of possible inflammatory complications.21 There is little attention to unwanted drug-drug or drug-supplement interactions.

This article was published in J Clin Psychopharmacol and referenced in Clinics in Mother and Child Health

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