Author(s): Chen ST, Geller AC, Tsao H
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Cutaneous malignant melanoma (CMM) has been increasing steadily in incidence over the past 30 years. Recent studies have explored associations between CMM and varying physiologic risk factors, such as nevi or hair and eye color, in addition to historical features such as a personal history of nonmelanoma skin cancer (NMSC), childhood cancers, Parkinson's Disease, hormone exposure and family history of CMM. Genome-wide association studies have also uncovered many genetic determinants of CMM risk. Ultimately, ultraviolet (UV) radiation exposure remains the most important modifiable risk factor for CMM. Organ transplant recipients, and nonsteroidal anti-inflammatory usage may also play a role. While risk factors are important to identify, effective campaigns to reduce the burden of disease through early detection and prevention are essential. We present detailed data regarding these facets of care for the CMM patient, and provide an update on the epidemiology of CMM.
This article was published in CurrDermatol Rep
and referenced in Immunotherapy: Open Access