Author(s): Novotn L, Vachlkov A, Biggs D
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Abstract Ursolic acid, UA, as a pentacyclic triterpene is of interest to scientists in the area of oncology because of its cytotoxicity, induction of differentiation, anti-mutagenic, antiviral and anti-invasive activities. UA is capable of inducing apoptosis in tumor cells on one side and to prevent malignant transformation of normal cells on the other side. It also interferes with numerous enzymes, including the ones serving directly to DNA synthesis. The aim of this review is to summarize reports on UA biological properties and to show its main anti-tumor effects and chemopreventive properties in normal cells.
This article was published in Neoplasma
and referenced in Journal of Computer Science & Systems Biology