alexa Use of a new dual-antigen enzyme-linked immunosorbent assay to detect and characterize the human antibody response to the human immunodeficiency virus type 2 envelope gp125 and gp36 glycoproteins.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Marcelino JM, Barroso H, Gonalves F, Silva SM, Novo C, , Marcelino JM, Barroso H, Gonalves F, Silva SM, Novo C,

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Abstract A dual-antigen enzyme-linked immunosorbent assay specific for human immunodeficiency virus type 2 (HIV-2) envelope proteins, ELISA-HIV2, was developed with two new recombinant polypeptides, rpC2-C3 and rgp36, derived from the HIV-2 envelope. The diagnostic performance was determined with HIV-2, HIV-1, and HIV-1/2 samples. Both polypeptides showed 100\% specificity. Clinical sensitivity was 100\% for rgp36 and 93.4\% for rpC2-C3. ELISA-HIV2 may be used for the specific diagnosis and confirmation of HIV-2 infection.
This article was published in J Clin Microbiol and referenced in Journal of AIDS & Clinical Research

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