Author(s): Jeffcoat M, Parry S, Gerlach RW, Doyle MJ
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Abstract OBJECTIVE: We sought to determine if treatment of periodontal disease during pregnancy with an alcohol-free antimicrobial mouth rinse containing cetylpyridinium chloride impacts the incidence of preterm birth (PTB) in a high-risk population. STUDY DESIGN: This single-blind clinical trial studied pregnant women (6-20 weeks' gestation) with periodontal disease who refused dental care. Subjects receiving mouth rinse were compared to designated controls who did not receive rinse (1 rinse:2 controls), balanced on prior PTB and smoking. Primary outcome was PTB <35 weeks. RESULTS: In all, 226 women were included in the analysis (71 mouth rinse subjects, 155 controls). Incidence of PTB <35 weeks was lower in the rinse group compared to controls (5.6\% and 21.9\% respectively, P < .01); relative risk was 0.26 (95\% confidence interval, 0.096-0.70). Gestational age and birthweight were significantly higher in the rinse group (P < .01). CONCLUSION: A nonalcohol antimicrobial mouth rinse containing cetylpyridinium chloride was associated with decreased incidence of PTB <35 weeks. Copyright © 2011 Mosby, Inc. All rights reserved.
This article was published in Am J Obstet Gynecol
and referenced in Journal of Antivirals & Antiretrovirals