Author(s): LozanoCalderon SA, Colman MW, Raskin KA, Hornicek FJ, Gebhardt M
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Abstract Bisphosphonates are medications known to decrease bone resorption by inhibiting osteoclastic activity. They are the first-line therapy for the treatment of osteoporosis because a significant body of literature has proved their efficacy in reducing the risk of fracture in the hip, spine and other nonvertebral osseous sites. In addition, the use of bisphosphonates has significantly decreased morbidity and increased survival, and they have also proved to be cost-effective. Unexpected adverse effects have been reported recently, but the benefit of bisphosphonates use outweighs the risks. This article reviews the current use of bisphosphonates in orthopedic surgery. Copyright © 2014 Elsevier Inc. All rights reserved.
This article was published in Orthop Clin North Am
and referenced in Journal of Spine