alexa Useful immunohistochemical markers for distinguishing Paget cells from Toker cells.
Dermatology

Dermatology

Dermatology and Dermatologic Diseases

Author(s): Park S, Suh YL

Abstract Share this page

Abstract AIMS: Toker cells (TCs) are normal components of the nipple epidermis. Because of their morphological and immunohistochemical similarities to mammary Paget cells (PCs), their presence may lead to a mistaken diagnosis of Paget's disease. The objective of this study was to identify immunohistochemical markers that are able to distinguish TCs from mammary PCs. METHODS: Nipple tissue, derived from surgical specimens following radical mastectomy for breast cancer, was obtained from 30 cases diagnosed with TCs and 30 cases of mammary Paget's disease (MPD). The tissue was examined by immunohistochemistry using antibodies to c-erbB-2, cytokeratin (CK)7, Ki-67 and oestrogen receptor (ER). RESULTS: TCs were consistently positive for CK7 and ER but negative for c-erbB-2. TCs either did not express Ki-67 or expressed very low levels with only 1-3 positive cells per high-power field. In contrast, MPD tended strongly to express both Ki-67 and c-erbB-2. CONCLUSIONS: Results suggested that TCs and mammary PCs differ substantially in their expression of ER, c-erbB-2 and Ki-67, although they share immunoreactivity to CK7. Both Ki-67 and c-erbB-2 were consistently positive in mammary PCs but almost always negative in TCs, while ER was consistently positive in TCs. Therefore, a combination of these markers may allow TCs to be distinguished from mammary PCs. This article was published in Pathology and referenced in Dermatology and Dermatologic Diseases

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords