alexa Usefulness of CINtec® PLUS p16 Ki-67 double-staining in cytological screening of cervical cancer.
Nephrology

Nephrology

Journal of Nephrology & Therapeutics

Author(s): Yoshida T, Sano T, Kanuma T, Inoue H, Itoh T,

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Abstract OBJECTIVE: This study evaluated the usefulness of p16(INK4a)/Ki-67 as a new biomarker in the diagnosis of human papillomavirus (HPV)-related cervical lesions. STUDY DESIGN: From 69 women with previous positive cytology, clinician-collected (CC) samples were obtained using a Cervex-Brush┬«. One month later, self-collected (SC) material was acquired using a Rovers┬« Viba-Brush. Liquid-based cytology specimens were prepared from both samples, and then the grades of squamous intraepithelial lesions (SIL) were determined; following immunostaining with CINtec┬« PLUS, HPV status was analyzed using a linear array. RESULTS: The mean double-positive cell scores (SCORE) in the CC samples were 3.2 in samples negative for intraepithelial lesions or malignancy, 1.3 in atypical squamous cells of undetermined significance, 87.1 in low-grade SIL, and 367 in high-grade SIL. According to HPV risk type, the mean SCORE was 16 in samples negative for HPV, 8.4 in low-risk HPV, 143 in high-risk HPV other than type 16, and 420 in HPV16 - with a statistical significance between high-risk HPV and type 16 (p < 0.05). The SCORE of the SC group was lower than that of the CC group because of the limited number of cells collected. CONCLUSIONS: The SCORE showed a significant correlation with HPV16 compared with lesser-degree lesions. CINtec PLUS is useful as a diagnostic marker of progression of lesions and a surrogate marker of an elevated risk of high-grade lesions with HPV16. Copyright ┬ę 2011 S. Karger AG, Basel. This article was published in Acta Cytol and referenced in Journal of Nephrology & Therapeutics

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