alexa Using Lean Six Sigma® Tools to Compare INR Measurements from Different Laboratories Within a Community.
Haematology

Haematology

Journal of Blood Disorders & Transfusion

Author(s): Authors Hurley B, Levett JM, Huber C, Taylor TL

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Excerpt Whenever measurements are taken on a patient or health care process, the measurement system must be analyzed in order to verify that it is adequate for the application. A Gage Repeatability and Reproducibility (R&R) study was performed to determine if blood samples taken from a patient on warfarin have the same International Normalized Ratio (INR) results when analyzed in different labs (reproducibility) and when analyzed multiple times in the same lab (repeatability). Results showed a statistically significant difference among labs. The therapeutic range for INR is typically 2.0 to 3.0, yet the data showed a difference in INR of 0.4 among labs on a small sample of 10 warfarin patients, almost 50 percent of the range. Root cause analysis revealed that the normalizing number (mean normal prothrombin time, MNPT) utilized in one of the labs varied greatly from other area labs. The team determined a new qualification process for MNPT to keep results consistent across all the labs.
This article was published in Using Lean Six Sigma® Tools to Compare INR Measurements from Different Laboratories Within a Community and referenced in Journal of Blood Disorders & Transfusion

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