alexa Validation of six closely linked STRs located in the chromosome X centromere region.
General Science

General Science

Journal of Forensic Research

Author(s): Edelmann J, Hering S, Augustin C, Kalis S, Szibor R, Edelmann J, Hering S, Augustin C, Kalis S, Szibor R

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Abstract We propose that clusters of closely linked markers, which segregate as stable haplotypes, provide a high potential to solve complex kinship cases. It is known that the X-chromosomal centromere region shows an extremely low degree of recombination. Hence, we focused our interest on the region between 56 and 64 Mb distant from the Xp telomere and considered 6 STRs which are now registered in the Genome Data Base as DXS10161, DXS10159, DXS10162, DXS10163, DXS10164, and DXS10165. All of these markers show a tetranucleotide or pentanucleotide structure and exhibit high or medium polymorphic information content. As a peculiarity, DXS10163 is a combination of a pentanucleotide STR and an 18 bp INDEL polymorphism. We report here the primer sequences, the repeat structures, the allele distributions and parameters of forensic interest for a German population sample. This article was published in Int J Legal Med and referenced in Journal of Forensic Research

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