Author(s): Kontodimopoulos N, Pappa E, Niakas D, Yfantopoulos J, Dimitrakaki C,
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Abstract OBJECTIVES: The main purpose of this study was to assess the construct validity of the Greek EQ-5D instrument in measuring health-related quality of life, as well as to address the issues of concurrent validity, internal consistency reliability, and sensitivity. METHODS: A stratified, representative sample (n = 1388) of the Greek general population was approached for interview (response rate 72.4\%). The survey included the EQ-5D, the SF-36, and questions on sociodemographic and clinical characteristics of the sample. RESULTS: The EQ-5D dimensions, the EQ visual analog scale, and the UK-based utility index were capable of distinguishing between groups of respondents, in the expected manner, on the basis of sex, age, education, socioeconomic status, self-reported health problems, and health services utilization, thus providing evidence of construct validity. Convergent and divergent validity of the EQ-5D descriptive system were supported by expected relationships with SF-36 scale and summary scores. Additionally, reporting a problem in a given EQ dimension was generally associated with lower SF-36 scores, supporting concurrent validity. Internal consistency reliability and sensitivity were also satisfactorily demonstrated. CONCLUSIONS: The results provide initial support for the construct validity of the EQ-5D in Greece, and, in conjunction to future studies addressing test-retest reliability and responsiveness, they support administering the instrument in health status studies, which in turn can contribute to transnational comparisons.
This article was published in Value Health
and referenced in Pharmacoeconomics: Open Access