alexa Vascular density and VEGF expression in hepatic lesions.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Brodsky SV, Mendelev N, Melamed M, Ramaswamy G

Abstract Share this page

Abstract BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor worldwide and the third most common cause of cancer-related death. HCC is a hypervascular tumor expressing several angiogenic factors. The correlation between plasma levels of Vascular Endothelial Growth Factor (VEGF) and the survival of patients with HCC was demonstrated earlier. However, a relationship between the expression of VEGF and vascular density in the HCC and non-malignant hepatic parenchyma has not been investigated. MATERIAL AND METHODS: We studied the expression of VEGF and vascular density in normal hepatic parenchyma, cirrhosis and HCC using a computer-based analysis of immunohistochemical stainings and confirmed it by Western Blot. RESULTS: The vascular density in the areas of HCC and internodular fibrotic tissue in cirrhotic liver was significantly higher (185\%; 146\% respectively) than in non-neoplastic hepatic parenchyma. Additionally, cirrhotic nodules were characterized by significantly lower vascularization (71\%) compared with normal liver. There was a strong correlation between the levels of VEGF expression in tissue and the number of vessels (r=0.98, R2=0.9696). CONCLUSION: Cirrhosis and HCC are characterized by different degrees of vascularization, which has been quantitated by a novel computer-based analysis of immunohistochemical stainings. One of the major stimuli for angiogenesis in these liver diseases could be VEGF, as the VEGF expression was higher in HCC and diminished in cirrhotic nodules, thus strongly correlating with the degree of vascularization. Our findings demonstrate that angiogenesis may play an important role in the pathogenesis of these conditions.
This article was published in J Gastrointestin Liver Dis and referenced in Journal of Carcinogenesis & Mutagenesis

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords