alexa Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
Pathology

Pathology

Journal of Clinical & Experimental Pathology

Author(s): Holash J

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In contrast with the prevailing view that most tumors and metastases begin as avascular masses, evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels. This coopted host vasculature does not immediately undergo angiogenesis to support the tumor but instead regresses, leading to a secondarily avascular tumor and massive tumor cell loss. Ultimately, however, the remaining tumor is rescued by robust angiogenesis at the tumor margin. The expression patterns of the angiogenic antagonist angiopoietin-2 and of pro-angiogenic vascular endothelial growth factor (VEGF) suggest that these proteins may be critical regulators of this balance between vascular regression and growth.

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This article was published in Science and referenced in Journal of Clinical & Experimental Pathology

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