alexa VIP decreases TLR4 expression induced by LPS and TNF-alpha treatment in human synovial fibroblasts.


Journal of Clinical & Experimental Neuroimmunology

Author(s): Juarranz Y, GutirrezCaas I, Arranz A, Martnez C, Abad C

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It has been demonstrated that VIP produces beneficial effects both in a murine model of rheumatoid arthritis and in human rheumatoid synovial fibroblasts through the modulation of proinflammatory mediators. Toll-like receptors (TLRs) play a key role in the immediate recognition of microbial surface components by immune cells prior to the development of adaptative microbe-specific immune responses. In this study, we demonstrate that VIP decreases lipopolysaccharide (LPS) and TNF-alpha-induced expression of TLR4 and its correlation with the production of CCL2 and CXCL8 chemokines in human synovial fibroblasts from patients with rheumatoid arthritis and osteoarthritis. Our results add a new step for the use of VIP, as a promising candidate, for the treatment of rheumatoid arthritis.

This article was published in Ann N Y Acad Sci. and referenced in Journal of Clinical & Experimental Neuroimmunology

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