Author(s): Bulterys PL, Dalai SC, Katzenstein DA, Bulterys PL, Dalai SC, Katzenstein DA
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Abstract Great progress has been made in understanding the pathogenesis, treatment, and transmission of HIV and the factors influencing the risk of mother-to-child transmission (MTCT). Many questions regarding the molecular evolution and genetic diversity of HIV in the context of MTCT remain unanswered. Further research to identify the selective factors governing which variants are transmitted, how the compartmentalization of HIV in different cells and tissues contributes to transmission, and the influence of host immunity, viral diversity, and recombination on MTCT may provide insight into new prevention strategies and the development of an effective HIV vaccine. Copyright © 2010 Elsevier Inc. All rights reserved.
This article was published in Clin Perinatol
and referenced in Journal of AIDS & Clinical Research