Author(s): Dey M, Ulasov IV, Lesniak MS
Abstract Share this page
Abstract Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
This article was published in Cancer Lett
and referenced in Brain Disorders & Therapy