alexa Virotherapy against malignant glioma stem cells.


Brain Disorders & Therapy

Author(s): Dey M, Ulasov IV, Lesniak MS

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Abstract Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
This article was published in Cancer Lett and referenced in Brain Disorders & Therapy

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